Unit SYNTHETIC ASPECTS IN THE PREPARATION OF MACRO AND BIOMOLECULES
- Course
- Industrial pharmacy
- Study-unit Code
- A003603
- Curriculum
- In all curricula
- Teacher
- Luca Sancineto
- Teachers
-
- Luca Sancineto
- Hours
- 32 ore - Luca Sancineto
- CFU
- 4
- Course Regulation
- Coorte 2023
- Offered
- 2023/24
- Learning activities
- Affine/integrativa
- Area
- Attività formative affini o integrative
- Academic discipline
- CHIM/06
- Type of study-unit
- Opzionale (Optional)
- Type of learning activities
- Attività formativa monodisciplinare
- Language of instruction
- Italian
- Contents
- Particular attention will be devoted to the chemistry of peptides, carbohydrates and their modified analogues. The main synthetic and purification strategies will be introduced, as well as the methodologies for studying the conformational aspects using spectroscopic techniques. Most of the approaches for the study of the interactions of macromolecules with their respective biological targets will be presented.
- Reference texts
- Handouts provided by the professor and published on Unistudium together with teaching material uploaded from time to time.
- Educational objectives
- At the end of the course the students will be able to deeply understand the structure and function of the main biological molecules and their ability to coordinate with each other in biological systems; in addition students will be able to apply the principles of synthetic chemistry to the preparation of biomolecules; understand the basic concepts of supramolecular assembly.
- Prerequisites
- Students must possess skills in the field of Organic Chemistry and Biochemistry in accordance with the year of the course attended.
- Teaching methods
- The course is based on theoretical lectures with examples of literature related to the most recent and advanced studies on the topic.
- Learning verification modality
- The exam consists of an oral test. Initially students will be invited to present a topic of their choice. Other questions can be asked to the candidate to complete the presentation. The final grade will be formulated by assessing the overall knowledge of the candidate for the subject.
- Extended program
- Peptides and peptidomimetics
- Functional derivatives of carboxylic acids, focus on the amide bond and synthetic strategies.
- Peptide synthesis: protecting groups in peptide synthesis, orthogonal protection methodologies, peptide bond formation, activation and coupling methods, solution and solid phase synthesis, use of microwave technology, native chemical ligation.
- Definition of peptidomimetic and classification
- Approaches for the development of peptidomimetics, conformational restrictions, use of non-natural amino acids
- Conformational analysis: circular dichroism, FT-IR, NMR.
- Chemistry of carbonyl compounds, aldehydes, ketones as functional groups characterizing sugars.
-Synthesis and purification of carbohydrates and their modified analogues.
-Methodologies for studying the conformational aspects using spectroscopic techniques.
- Techniques for studying the interactions of macromolecules with their respective biological targets and of macromolecules with each other, to give supramolecular complexes. - Obiettivi Agenda 2030 per lo sviluppo sostenibile
- 3, 4, 12