Unit SYSTEMIC PATHOLOGY V
- Course
- Medicine and surgery
- Study-unit Code
- GP004561
- Location
- PERUGIA
- Curriculum
- In all curricula
- Teacher
- Roberto Gerli
- CFU
- 12
- Course Regulation
- Coorte 2019
- Offered
- 2022/23
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa integrata
BLOOD DISEASES - MOD. 1
Code | GP004621 |
---|---|
Location | PERUGIA |
CFU | 2 |
Teacher | Cristina Mecucci |
Learning activities | Caratterizzante |
Area | Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica |
Academic discipline | MED/15 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | Emathopoiesis; Anemias: classifications; Abnormalities of erythroid shape and size; Iron deficiency; Megaloblastic anemias; Anemias associated to chronic diseases; Hemolysis; Inherited hemolytic diseases; Hemolysis due to external agents; Thalassemias; Aplastic anemias; Paroxystic Nocturnal Hemoglobinuria; Differential diagnosis of anemic syndromes. |
Reference texts | HARRISON’S PRINCIPLES OF MEDICINE TURA-ZINZANI |
Educational objectives | Knowledge of basichemopoiesis; Ability to evaluate normal and pathologic cell blood counts; Diagnosis of most important anemic syndromes. |
Prerequisites | Physiology, Anatomy, Molecular Medicine, General Pathology. |
Teaching methods | Teaching in class |
Learning verification modality | Oral exam |
Extended program | Emathopoiesis; Anemias: classifications; Abnormalities of erythroid shape and size; Iron deficiency; Megaloblastic anemias; Anemias associated to chronic diseases; Hemolysis; Inherited hemolytic diseases; Hemolysis due to external agents; Thalassemias; Aplastic anemias; Paroxystic Nocturnal Hemoglobinuria; Differential diagnosis of anemic syndromes. |
BLOOD DISEASES - MOD. 2
Code | GP004622 |
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Location | PERUGIA |
CFU | 1 |
Teacher | Maria Paola Martelli |
Teachers |
|
Hours |
|
Learning activities | Caratterizzante |
Area | Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica |
Academic discipline | MED/15 |
Type of study-unit | Obbligatorio (Required) |
DISEASES OF THE IMMUNE SYSTEM
Code | GP005656 |
---|---|
Location | PERUGIA |
CFU | 2 |
Teacher | Antonio Pierini |
Teachers |
|
Hours |
|
Learning activities | Caratterizzante |
Area | Medicina delle attività motorie e del benessere |
Academic discipline | MED/09 |
Type of study-unit | Obbligatorio (Required) |
MOLECULAR MEDICINE
Code | GP004623 |
---|---|
Location | PERUGIA |
CFU | 1 |
Teacher | Cristina Mecucci |
Teachers |
|
Hours |
|
Learning activities | Caratterizzante |
Area | Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica |
Academic discipline | MED/15 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | Technological approaches for the study of the genome. Leukemic and tumor stem cells, multistep process of oncogenesis, mechanisms of alteration of oncogenes, tumor suppressors, shelter genes and check-point genes. Clonal hematopoiesis and leukemia pathogenesis. Models of pathogenesis of congenital and acquired medullary insufficiencies. Models of pathogenesis of Acute Leukemia. Tyrosinchinase. Pathogenesis models of lymphoproliferative disorders. Myeloma pathogenesis models. Models of pathogenesis of solid tumors (lung, breast, colon). |
Reference texts | The material will be provided by professor |
Teaching methods | Frontal lessons Seminars |
Learning verification modality | Multiple choice quiz or oral exam |
Extended program | Technological approaches for the study of the genome. Leukemic and tumor stem cells, multistep process of oncogenesis, mechanisms of alteration of oncogenes, tumor suppressors, shelter genes and check-point genes. Models of pathogenesis of congenital and acquired medullary insufficiencies. Models of pathogenesis of Acute Leukemia. Tyrosinchinase. Pathogenesis models of lymphoproliferative disorders. Myeloma pathogenesis models. Models of pathogenesis of solid tumors (lung, breast, colon). |
REUMATHOLOGY
Code | GP005657 |
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Location | PERUGIA |
CFU | 2 |
Teacher | Roberto Gerli |
Teachers |
|
Hours |
|
Learning activities | Caratterizzante |
Area | Clinica delle specialità medico-chirurgiche |
Academic discipline | MED/16 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | ITALIAN |
Contents | Classification, epidemiology and pathogenesis of rheumatic disease. Clinical features of most common acute and chronic osteoarticular disease, inflammatory and not, of extra-articular rheumatism, of systemic autoimmunitary disease and of systemic vasculitides. |
Reference texts | REUMATOLOGIA per studenti e Medici di a cura di UNIREUMA. IDELSON GNOCCHI IV Ed. 2022. HARRISON et al. Principles of Internal Medicine XX Ed. McGraw Hill Ed. |
Educational objectives | At the end of the Course students are expected to recognize and define the peculiar features of most common chronic articular conditions, both inflammatory and degenerative, extra-articular rheumatic diseases, systemic autoimmune diseases and systemic vasculitis, from an etiologic, pathogenic and, most importantly, clinical point of view. In addition, the students are asked to prove the ability to recognize and interpret the laboratory tests specific for the aforementioned conditions and the most common instrumental procedures employed in rheumatology clinics. The students’ diagnostic approach based on signs and symptoms will also be evaluated. |
Prerequisites | In order to start Rheumatology lessons, the student should have good knowledge of anatomy and physiopathology and good skill in general phisical examination of the patient. |
Teaching methods | The Course includes 25 hours with 14 theoretical hours and 11 hours of practical skills and practical training or seminars. |
Other information | |
Learning verification modality | The exam includes a multiple choice written test (30 questions with up to 5 possible answers of which only 1 correct). Score: + 1 for correct answer, - 0.25 for wrong answer, 0 points for not done answer. Questions will cover all rheumatology topics and can be afforded with a basic knowledge of such topics. The test will be performed only if the pandemic risk will allow it. The oral exam is open to students who passed the first written test (with a score of at least 18/30) and includes wider questions aimed at evaluating theoretical and practical skills as well as deductive processes and communication. The average examination time is 20-25 minutes. |
Extended program | 1. Definition, classification and epidemiology of rheumatic diseases 2. The musculoskeletal system: anatomic and functional elements 3. Etiopathogenic mechanisms of rheumatic diseases 4. Signs and syntoms of rheumatic diseases 5. Laboratory and imaging diagnosis and synovial fluid analysis 6. Inflammatory joint diseases a) Rheumatoid arthritis and other related joint diseases b) Spondyloarthritis i. Ankylosing Spondylitis ii. Reactive arthritis iii. Psoriatic arthritis iv. Enteropathic arthritis c. Polymyalgia rheumatica 7. Connective tissue diseases a) Systemic lupus erythematosus b) Antiphospholipid syndrome c) Systemic sclerosis d)Polymyositis/Dermatomyositis/Inflammatory myopathies/Anti-synthetasis antibody syndrome e) Sjögren's syndrome f) Overlap syndromes, included mixed connective tissue disesase g) Undifferentiated connective tissue diseases (UCTD) 8. Primary systemic vasculitides a) Large size-arteries: Takayasu arteritis, Horton arteritis b) Medium-size arteries: polyarteritis nodosa c) Medium and small-size vessels ANCA-associated (micropolyangioitis, granulomatosis with polyangioitis - Wegener's granulomatosis, with eosinophilic granulomatosis with polyangioitis - Churg-Strauss syndrome) 9. Small-size vessels a) Behçet's disease b) cryoglobulinemia c) IgA vasculitis - Schönlein-Henoch purpura 10. Septic and post-infective arthritis (rheumatic fever) 11. Microcrystal arthropaties (Gout, Calcium pyrophosphate dihydrate and hydroxyapatite deposition disorders) 12. Osteoarthritis 13. Localized and generalized extra-articular rheumatic diseases and fibromyalgia 14. Neurovascular and neurologic syndrome a) Raynaud 's phenomenon b) Carpal tunnel syndrome 15. Autoinflammatory disorders a. Adult Still disease 16. Miscellaneous disorders associated with rheumatologic manifestations a. Sarcoidosis |
PROFESSIONALISING TRAINING IN BLOOD DISEASES
Code | GP004624 |
---|---|
Location | PERUGIA |
CFU | 1 |
Teacher | Roberto Gerli |
Learning activities | Altro |
Area | Tirocini formativi e di orientamento |
Academic discipline | MED/15 |
Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Cristina Mecucci
- Teachers
- Cristina Mecucci
- Hours
- 25 ore - Cristina Mecucci
- Language of instruction
- Italian
- Contents
- Clinical activity in the hospital ward: general approach to the patient with blood count changes.
Discussion of normal and abnormal blood counts: anemia and erythrocytosis
leukopenias and leukocytosis
platelet disorders and platelet diseases
pancytopenias
General approach to the patient with lymphadenomegalyGeneral approach to the patient with splenomegaly - Reference texts
- Harrison's - Principles of Internal Medicine
Hoffbrand/Moss - Essential Haematology
Bosi, De Stefano, Di Raimondo, La Nasa – Manuale di Malattie del Sangue
Avvisati – Ematologia di Mandelli
Hoffman - Hematology basic principles and practice - Educational objectives
- http://www.med.unipg.it/ccl
- Prerequisites
- Attendance of the Blood Diseases course
- Teaching methods
- Training in hospital wards and laboratory
- Other information
- Site:
Reparto/Day Hospital Ematologia - Ospedale Santa Maria della Misericordia-Perugia - Learning verification modality
- Discussion of clinical cases. Practical exam n the hospital ward
- Extended program
- Clinical activity in the hospital ward: general approach to the patient with blood count changes.
Discussion of normal and abnormal blood counts: anemia and erythrocytosis
leukopenias and leukocytosis
platelet disorders and platelet diseases
pancytopenias
General approach to the patient with lymphadenomegalyGeneral approach to the patient with splenomegaly
Cognomi M-Z
- CFU
- 1
- Teacher
- Maria Paola Martelli
- Teachers
- Maria Paola Martelli
- Hours
- 25 ore - Maria Paola Martelli
PROFESSIONALISING TRAINING IN DISEASES OF THE IMMUNE SYSTEM
Code | GP005658 |
---|---|
Location | PERUGIA |
CFU | 1 |
Teacher | Roberto Gerli |
Learning activities | Altro |
Area | Tirocini formativi e di orientamento |
Academic discipline | MED/09 |
Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Antonio Pierini
- Teachers
- Antonio Pierini
- Hours
- 25 ore - Antonio Pierini
Cognomi M-Z
- CFU
- 1
- Teacher
- Antonio Pierini
- Teachers
- Antonio Pierini
- Hours
- 25 ore - Antonio Pierini
PROFESSIONALISING TRAINING IN MOLECULAR MEDICINE
Code | GP004625 |
---|---|
Location | PERUGIA |
CFU | 1 |
Teacher | Cristina Mecucci |
Learning activities | Altro |
Area | Tirocini formativi e di orientamento |
Academic discipline | MED/15 |
Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Cristina Mecucci
- Teachers
- Cristina Mecucci
- Hours
- 25 ore - Cristina Mecucci
- Language of instruction
- Italian
- Contents
- Technological approaches to genome surveys. Protocols and their applications.
- Educational objectives
- Ability to address diagnostic investigations and optimize procedures.
- Prerequisites
- Knowledge of the genetic basis of tumors.
- Teaching methods
- Tutor system in working groups.
- Learning verification modality
- During the exam
- Extended program
- Conventional cytogenetics. FISH, PCR, sequencing. Telomeres, Chromosomal instability test. Test on paraffin sections. Nucleic acids, separation. Microarrays.
Cognomi M-Z
- CFU
- 1
- Teacher
- Cristina Mecucci
- Teachers
- Cristina Mecucci
- Hours
- 25 ore - Cristina Mecucci
- Language of instruction
- Italian
- Contents
- Technological approaches to genome surveys. Protocols and their applications.
- Educational objectives
- Ability to address diagnostic investigations and optimize procedures.
- Prerequisites
- Knowledge of the genetic basis of tumors.
- Teaching methods
- Tutor system in working groups.
- Learning verification modality
- during the exam
- Extended program
- Conventional cytogenetics. FISH, PCR, sequencing. Telomeres, Chromosomal instability test. Test on paraffin sections. Nucleic acids, separation. Microarrays.
PROFESSIONALISING TRAINING IN REUMATHOLOGY
Code | GP005659 |
---|---|
Location | PERUGIA |
CFU | 1 |
Teacher | Roberto Gerli |
Learning activities | Altro |
Area | Tirocini formativi e di orientamento |
Academic discipline | MED/16 |
Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Roberto Gerli
- Teachers
- Roberto Gerli
- Hours
- 25 ore - Roberto Gerli
- Language of instruction
- Italian
- Contents
- Clinical activity with Rheumatologist, included clinical history, physical examination, diagnosis and therapeutic intervention; infusion of biotechnological agents; instrumental diagnosis by ultrasound evaluation of muscle-skeletal areas and ultrasound-driven interventions for joints, tendons, ...; diagnosis of microcirculation disorders by videocapillaroscopic examination; evaluations of foot and posture disorders.
- Reference texts
- REUMATOLOGIA per studenti e Medici a cura di UNIREUMA. IDELSON GNOCCHI IV Ed. 2022.
HARRISON et al. Principles of Internal Medicine XX Ed.
McGraw Hill Ed. - Educational objectives
- Results based on check of the acquired ability, behavior and interaction degree of the student.
- Prerequisites
- For the purpose of learning, the student should have good knowledge of anatomy and physiopathology and good skill in general phisical examination of the patient.
- Teaching methods
- Partecipation to the above described activities
- Learning verification modality
- For the professionalizing intership, there is no a specific exam, but this included in the final oral exam.
- Extended program
- 1. Definition, classification and epidemiology of rheumatic diseases
2. The musculoskeletal system: anatomic and functional elements
3. Etiopathogenic mechanisms of rheumatic diseases
4. Signs and syntoms of rheumatic diseases
5. Laboratory and imaging diagnosis and synovial fluid analysis
6. Inflammatory joint diseases
a) Rheumatoid arthritis and other related joint diseases
b) Spondyloarthritis
i. Ankylosing Spondylitis
ii. Reactive arthritis
iii. Psoriatic arthritis
iv. Enteropathic arthritis
c. Polymyalgia rheumatica
7. Connective tissue diseases
a) Systemic lupus erythematosus
b) Antiphospholipid syndrome
c) Systemic sclerosis
d)Polymyositis/Dermatomyositis/Inflammatory myopathies/Anti-synthetasis antibody syndrome
e) Sjögren's syndrome
f) Overlap syndromes, included mixed connective tissue disesase
g) Undifferentiated connective tissue diseases (UCTD)
8. Primary systemic vasculitides
a) Large size-arteries: Takayasu arteritis, Horton arteritis
b) Medium-size arteries: polyarteritis nodosa
c) Medium and small-size vessels ANCA-associated (micropolyangioitis, granulomatosis with polyangioitis - Wegener's granulomatosis, with eosinophilic granulomatosis with polyangioitis - Churg-Strauss syndrome)
9. Small-size vessels
a) Behçet's disease
b) cryoglobulinemia
c) IgA vasculitis - Schönlein-Henoch purpura
10. Septic and post-infective arthritis (rheumatic fever)
11. Microcrystal arthropaties (Gout, Calcium pyrophosphate dihydrate and hydroxyapatite deposition disorders)
12. Osteoarthritis
13. Localized and generalized extra-articular rheumatic diseases and fibromyalgia
14. Neurovascular and neurologic syndrome
a) Raynaud 's phenomenon
b) Carpal tunnel syndrome
15. Autoinflammatory disorders
a. Adult Still disease
16. Miscellaneous disorders associated with rheumatologic manifestations
a. Sarcoidosis
Cognomi M-Z
- CFU
- 1
- Teacher
- Carlo Perricone
- Teachers
- Carlo Perricone
- Hours
- 25 ore - Carlo Perricone